Endocrine Abstracts

Background: Struma ovarii is a germ cell tumor of the ovary containing ≥ 50% thyroid tissue and malignant struma ovarii (MSO) is a very rare disease containing papillary or follicular thyroid carcinomas (FTC). There is no consensus on optimal management for patients with MSO and no data on radioactive iodine (RAI) responsiveness. Here, we report two cases with RAI refractory MSO with NRAS mutation detected by next-generation sequencing (NGS). Case ...

Objective: Digital pathology is the process of scanning conventional slides and then digitally stitching consecutive images into digital slides that can be viewed, managed, and analyzed on a computer monitor. In this study, we evaluated the area of metastatic foci in cervical lymph node (LN) metastasis in application of digital pathology and prognostic implication for predicting structural recurrence in patients with papillary thyroid cancer (PTC).Method...

Objective: To evaluate computed tomography (CT) features for diagnosing metastatic cervical lymph nodes (LNs) in patients with differentiated thyroid cancer (DTC) and propose CT-based risk stratification system modified from the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) guidelines.Materials and Methods: A total of 463 LNs from 397 patients with DTC who underwent preoperative CT staging and US-guided fine needle aspiration of LNs were in...

Objective: To evaluate the effectiveness and safety of ultrasound-guided RFA for symptomatic distant metastasis of DTC.Methods: The medical records of 12 patients who underwent RFA for palliative treatment of 18 symptomatic distant metastases from thyroid cancer between January 2008 and December 2020 were analyzed. All patients were assessed for their degree of discomfort, and were evaluated periodically as outpatients, clinically, and by imaging and ser...

Background: Unlike excellent prognosis of classical papillary thyroid carcinoma (cPTC), certain pathological subtypes of aggressive variants of PTC (AV-PTC) are considered to have poor clinical outcome. However, the evidence of unfavorable outcome of AV-PTC is not clear because previous studies did not control other confounding factors contributed to clinical outcomes.Methods: This retrospective cohort study initially included 4339 patients with cPTC and...